7 012 Introductory Biology Assignments

Reading assignments include scientific articles, class handouts, online resources, and sections from the required text. Assignments for this course also used to include several readings from the MIT Biology Hypertextbook, but these have been removed as that site is no longer active. At this time there are no plans to re-present the materials.

Freeman, Scott. Biological Science. Upper Saddle River, NJ: Prentice Hall, 2002. ISBN: 9780130819239.

1Introductionp. vi
Chapter 1
pp. 90-94
2Biochemistry 1Chapter 2
pp. 70-77
3-5Biochemistry 2

Biochemistry 3

Biochemistry 4
Chapter 3
Chapter 6
6Genetics 1Chapter 10, pp. 194-201
7Genetics 2Chapter 10, pp. 201-214
8Genetics 3Chapter 8.2 (pp. 159-164) and pp. 176-191
9Human GeneticsChapter 17.2, pp. 339-342
10Molecular Biology 1pp. 59-61, Chapter 11, 12
11Molecular Biology 2Chapter 13, pp. 252-259
 Quiz 1, Lectures 1-10 
12Molecular Biology 3Chapter 13, pp. 259-271, 244-246
13Gene RegulationChapter 14
14Protein LocalizationProtein Trafficking. pp. 95-103
15-18Recombinant DNA 1

Recombinant DNA 2

Recombinant DNA 3

Recombinant DNA 4
Spencer, Charlotte A. Genetic Testimony: A Guide to Forensic DNA Profiling. San Francisco, CA: Benjamin Cummings, 2003. ISBN: 9780131423381.
 Quiz 2, Lectures 11-17 
19Cell Cycle/Signalingpp. 164-168, 864-867
20CancerWeinberg, R. A. "How Cancer Arises." Sci Am. 275, no. 3 (September 1996): 62-70.

———. "Finding the Anti-oncogene." Sci Am. 259, no. 3 (September 1988): 44-51.
21Virology/Tumor VirusesChapter 26, pp. 501-507
Viruses (PDF)
22-23Immunology 1

Immunology 2
Chapter 46
Humoral Immunology (PDF)
24AIDSChapter 26.2, pp. 507-516
AIDS (PDF)
25GenomicsLander, E. S., and R. A. Weinberg. "Genomics: Journey to the Center of Biology." Science 287, no. 5459 (March 10, 2000): 1777-82.
 Quiz 3, Lectures 18-24 
26Nervous System 1Chapter 42, pp. 806-817
27Nervous System 2Chapter 42, pp. 817-822
28Nervous System 3Chapter 42, pp. 822-827
29-30Stem Cells/Cloning 1

Stem Cells/Cloning 2
pp. 346, 406-407, 364-367
Essay on p. 826
Growth and Differentiation, a Case of Hematopoiesis (PDF)
31Molecular Medicine 1NCI Gleevec Article
pp. 330
32Molecular EvolutionGenetics and Geneology, Why Y?
The Family Lemba (PBS Nova)
The Family Cohanim (PBS Nova)
Did Thomas Jefferson Father Slave Children? (PBS Nova)
33Molecular Medicine 2Essay: pp. 782-783
The Cholesterol Quartet
Familial Hypercholesterolemia
34Human Polymorphisms and Cancer Classification 
35Future of Biology 

Course Features

Course Highlights

This course features a complete set of video lectures by Professor Eric Lander, Director of the Broad Institute at MIT and a principal leader of the Human Genome Project and Professor Robert A. Weinberg, winner of the 1997 National Medal of Science.

Education development efforts for these introductory biology courses are one of many activities conducted by the HHMI Education Group at MIT. This group focuses on curriculum development work for creating teaching tools in undergraduate biology courses.

Course Description

The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.

7.012 focuses on the exploration of current research in cell biology, immunology, neurobiology, genomics, and molecular medicine.

Acknowledgments

The study materials, problem sets, and quiz materials used during Fall 2004 for 7.012 include contributions from past instructors, teaching assistants, and other members of the MIT Biology Department affiliated with course #7.012. Since the following works have evolved over a period of many years, no single source can be attributed.

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